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  4. Solutol HS-15

Solutol HS-15  (Synonyms: Polyethylene glycol 12-hydroxystearate)

Cat. No.: HY-Y1893
SDS COA Handling Instructions

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Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.

For research use only. We do not sell to patients.

Solutol HS-15 Chemical Structure

Solutol HS-15 Chemical Structure

CAS No. : 61909-81-7

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Based on 11 publication(s) in Google Scholar

Solutol HS-15 Related Antibodies

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Description

Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer[1].

In Vitro

Solutol HS-15 is used to increase the aqueous solubility of Biopharmaceutical Classification System (BCS) Class 2 and 4 lipophilic molecules. Solutol HS-15 has shown an enhancement in permeability of medium sized biological drugs across epithelia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Solutol HS-15 Related Antibodies
Formula

(C2H4O)nC18H36O3
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

CCCCCCC(O)CCCCCCCCCCC(OCCO)=O.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (Need ultrasonic)

H2O : 25 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

SDS (393 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[1]

For both MTS and LDH cell viability assays, cells are seeded at a density of 1×104 cells on 96-well plates and cultured for a minimum of 24 h. Solutol HS-15 (in 25 mM HBSS:HEPES, pH 7.4) solutions are applied at concentrations above and below the critical micelle concentration (CMC) (0.01 mM to 20 mM) and cytotoxicity is determined using the MTS and LDH assays. 25 mM HBSS:HEPES is used as a negative control and Triton-X 100 (3 mM) as a positive control. Following 3 h incubation, the MTS reagent in media and LDH working solution are added to the cells and the cells are incubated for a further 3 h at 37°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Solutol HS-15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solutol HS-1561909-81-7Polyethylene glycol 12-hydroxystearateSolutol HS15Solutol HS 15Biochemical Assay ReagentsSolutolHS-15Inhibitorinhibitorinhibit

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