2. Biochemical Assay Reagents
  3. Co-solvents

Co-solvents

Co-solvents are substances added to solutions of drugs that are poorly soluble or insoluble, which enhance their solubility. They address the issue of drugs being insoluble or having insufficient solubility in water, thereby affecting their therapeutic efficacy and failing to meet experimental requirements.
The degree of drug solubility is crucial for its bioavailability, making the enhancement of solubility a key aspect in the development and application of pharmaceutical formulations.
MCE provides a full range of co-solvent, Including cyclodextrins, oils, solvents, polymers, surfactants, and multi-component reagents, all with stringent endotoxin control to boost drug solubility and support our clients' research endeavors.

Co-solvents (86):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Y0320
    Dimethyl sulfoxide, meets analytical specification of Ch.P. 67-68-5 99.99%
    Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties.
    MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).
    Dimethyl sulfoxide, meets analytical specification of Ch.P.
  • HY-17031
    SBE-β-CD 182410-00-0 99.89%
    SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents.
    SBE-β-CD
  • HY-Y1893
    Solutol HS-15 61909-81-7
    Solutol HS-15, a Macrogol 15 hydroxy stearate, is a permeability enhancer.
    Solutol HS-15
  • HY-101461
    Methyl-β-cyclodextrin 128446-36-6 99.95%
    Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation.
    Methyl-β-cyclodextrin
  • HY-Y1903
    Phosal 50 PG 774594-96-6
    Phosal 50 PG is a cosolvent (standardised phosphatidylcholine concentrate). Phosal 50 PG as a carrier for lipophilic compounds, can improve the absorption, efficacy and therapeutic index of the active ingredient.
    Phosal 50 PG
  • HY-W042558
    N-Succinimidyl myristate 69888-86-4
    N-Succinimidyl myristate is a biochemical reagent.
    N-Succinimidyl myristate
  • HY-166519
    (2-Hydroxypropyl)-α-cyclodextrin (MW 1180) 128446-33-3
    (2-Hydroxypropyl)-α-cyclodextrin (MW 1180) is a cyclic oligosaccharide derivative that acts as a solubilizer in various experiments.
    (2-Hydroxypropyl)-α-cyclodextrin (MW 1180)
  • HY-W130500A
    Ethylene glycol monohexyl ether, 99% 112-25-4
    Ethylene glycol monohexyl ether, 99% is a multifunctional solvent.
    Ethylene glycol monohexyl ether, 99%
  • HY-Y0842
    Formamide 75-12-7 99.90%
    Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. It induces apoptosis by promoting the formation of cyclic nucleotides and the phosphorylation and dephosphorylation processes of nucleotides, making it useful in cancer research. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.
    Formamide
  • HY-Y1892
    Gelucire 44/14 121548-04-7
    Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.
    Gelucire 44/14
  • HY-Y1275
    N-Methylpyrrolidone 872-50-4 99.99%
    N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.
    N-Methylpyrrolidone
  • HY-W042416
    N,N-Dimethylacetamide 127-19-5 99.96%
    N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
    N,N-Dimethylacetamide
  • HY-Y0873C
    PEG3350 25322-68-3
    PEG3350 (Polyethylene glycol 3350) a neutral polymer of molecular weight 3350. PEG3350 used as an excellent solvent for a large number of substances.
    PEG3350
  • HY-Y1889A
    Sodium carboxymethyl cellulose (MW 250000) 9004-32-4
    Sodium carboxymethyl cellulose (CMC-Na) (MW 250000) is a sodium salt of carboxymethyl cellulose. Sodium carboxymethyl cellulose has adsorption and corrosion inhibition on low-carbon steel in an acidic medium. Sodium carboxymethyl cellulose can be used as a thickener, paste and barrier agent.
    Sodium carboxymethyl cellulose (MW 250000)
  • HY-Y1889
    Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) 9004-32-4
    Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s) is the sodium salt of cellulose arboxymethyl and frequently used as viscous agent, paste and barrier agent.
    Sodium carboxymethyl cellulose (Viscosity:5000-15000 mPa.s)
  • HY-Y0873K
    PEG200 25322-68-3 ≥98.0%
    PEG200 (Polyethylene glycol 200), a neutral polymer of molecular weight 200, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.
    PEG200
  • HY-18593
    Mal-β-CD 104723-60-6 ≥98.0%
    Mal-β-CD is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.
    Mal-β-CD
  • HY-137234
    DM-β-CD 51166-71-3 99.9%
    DM-β-CD (2,6-Di-O-methyl-β-cyclodextrin) is a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is usually used as a solubilizer and carrier for poorly soluble drugs in pharmaceutical preparations. Furthermore, it has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides, and heavy metals.
    DM-β-CD
  • HY-Y0873Q
    PEG20000 25322-68-3
    PEG20000 (Polyethylene glycol 20000) can be used as a solubilizer. PEG20000 is a kind of biological materials or organic compounds that are widely used in life science research, can be degraded by bacteria.
    PEG20000
  • HY-D1005H
    Poloxamer 188 (F68) 9003-11-6
    Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
    Poloxamer 188 (F68)