2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. SOS1/EGFR-IN-2

SOS1/EGFR-IN-2 (Compound 4) is a SOS1 and EGFR dual inhibitor with IC50s of 8.3 and 14.6 nM, respectively. SOS1/EGFR-IN-2 exhibits significant antiproliferative effect on the cancer cells haboring various KRAS mutants.

For research use only. We do not sell to patients.

SOS1/EGFR-IN-2 Chemical Structure

SOS1/EGFR-IN-2 Chemical Structure

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SOS1/EGFR-IN-2 Related Antibodies

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Description

SOS1/EGFR-IN-2 (Compound 4) is a SOS1 and EGFR dual inhibitor with IC50s of 8.3 and 14.6 nM, respectively. SOS1/EGFR-IN-2 exhibits significant antiproliferative effect on the cancer cells haboring various KRAS mutants[1].

Molecular Weight

490.52

Formula

C25H29F3N4O3
SMILES

C[C@@H](NC1=C2C(C=C(OC)C(OCCCN3CCOCC3)=C2)=NC=N1)C4=CC=CC(C(F)(F)F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SOS1/EGFR-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOS1/EGFR-IN-2EGFREpidermal growth factor receptorErbB-1HER1son of sevenless 1epidermal growth factor receptorKRAS mutantsInhibitorinhibitorinhibit

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