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Sotigalimab  (Synonyms: APX005M)

Cat. No.: HY-P99049 Purity: 98.90%
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Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma.

For research use only. We do not sell to patients.

CAS No. : 2305607-45-6

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Description

Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma[1][2].

In Vitro

Sotigalimab (0-100 nM, 48 h) increases the expression of immune co-stimulatory molecules CD86 and MHC II; thereby increasing the expression of HLA-DR in human primary B cells[3].
Sotigalimab (0-100 nM, 5 days) promote T cell responses, stimulates the T cell proliferation and IFN-γ secretion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Human CD8 T cell
Concentration: 0-10 nM
Incubation Time: 5 days
Result: Promoted the proliferation of tumor-infiltrating T cells.
In Vivo

Sotigalimab (0.3-30 mg/kg, iv, once weekly for 4 weeks) reduces the number of peripheral B lymphocytes without adverse effects on other organ systems in cynomolgus monkeys[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey models[3]
Dosage: 0.3-30 mg/kg
Administration: iv, once weekly for 4 weeks
Result: Reduced the number of peripheral B lymphocytes within 24 hours after administration.
Clinical Trial
Molecular Weight

144540.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Sotigalimab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sotigalimab
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HY-P99049
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