SP-471

Cat. No.: HY-144646: FAQs
Data Sheet Handling Instructions

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SP-471 is a potent dengue virus (DENV) protease inhibitor with IC₅₀ value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.

For research use only. We do not sell to patients.

SP-471 Chemical Structure

CAS No. : 2768010-39-3

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5 mg	USD 520	Ask For Quote & Lead Time
10 mg	USD 866	Ask For Quote & Lead Time
25 mg	USD 1820	Ask For Quote & Lead Time
50 mg	USD 2900	Ask For Quote & Lead Time
100 mg	USD 4500	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Description

SP-471 is a potent dengue virus (DENV) protease inhibitor with IC₅₀ value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV^[1].

IC₅₀ & Target

IC₅₀: 18 μM (DENV)^[1]

In Vitro

SP-471 (10 μM; 48 hours) exhibits an EC₅₀ value of 48.13 μM and CC₅₀ over 100 μM for ADE infection in human PBMCs^[1]. ^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human peripheral blood mononuclear cells (infected with ADE)^[1]
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Resulted in an EC₅₀ value of 48.13 μM and CC₅₀ over 100 μM for ADE infection in human PBMCs.

Molecular Weight

572.50

Formula

C₃₃H₂₆BrN₅

CAS No.

2768010-39-3

SMILES

N=C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(C(N)=N)=C6)=C4)=C2)=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Swarbrick C, Zogali V, Chan KWK, et al. Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease. Eur J Med Chem. 2021;224:113695. [Content Brief]

SP-471 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-4712768010-39-3SP471SP 471Dengue virusFlavivirusVirus ProteaseDENVRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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