2. Anti-infection
  3. Dengue virus Flavivirus Virus Protease
  4. SP-471

SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.

For research use only. We do not sell to patients.

SP-471 Chemical Structure

SP-471 Chemical Structure

CAS No. : 2768010-39-3

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Based on 1 publication(s) in Google Scholar

SP-471 Related Antibodies

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Description

SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV[1].

IC50 & Target

IC50: 18 μM (DENV)[1]
In Vitro

SP-471 (10 μM; 48 hours) exhibits an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs[1]. [1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP-471 Related Antibodies

Cell Viability Assay

Cell Line: Human peripheral blood mononuclear cells (infected with ADE)[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Resulted in an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs.
Molecular Weight

572.50

Formula

C33H26BrN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(C(N)=N)=C6)=C4)=C2)=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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SP-471 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-4712768010-39-3SP471SP 471Dengue virusFlavivirusVirus ProteaseDENVRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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HY-144646
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