2. Anti-infection
  3. Dengue virus Flavivirus Virus Protease
  4. SP-471

SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.

For research use only. We do not sell to patients.

SP-471 Chemical Structure

SP-471 Chemical Structure

CAS No. : 2768010-39-3

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SP-471 Related Antibodies

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Description

SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV[1].

IC50 & Target

IC50: 18 μM (DENV)[1]
In Vitro

SP-471 (10 μM; 48 hours) exhibits an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs[1]. [1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP-471 Related Antibodies

Cell Viability Assay

Cell Line: Human peripheral blood mononuclear cells (infected with ADE)[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Resulted in an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs.
Molecular Weight

572.50

Formula

C33H26BrN5
CAS No.
SMILES

N=C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(C(N)=N)=C6)=C4)=C2)=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SP-471 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-4712768010-39-3SP471SP 471Dengue virusFlavivirusVirus ProteaseDENVRNA synthesisHuman PBMCsHuh7Inhibitorinhibitorinhibit

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