2. Anti-infection
  3. Bacterial Antibiotic
  4. Sparfloxacin

Sparfloxacin  (Synonyms: CI-978; AT-4140)

Cat. No.: HY-B0308 Purity: 99.93%
COA Handling Instructions

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Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.

For research use only. We do not sell to patients.

Sparfloxacin Chemical Structure

Sparfloxacin Chemical Structure

CAS No. : 110871-86-8

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100 mg USD 72 In-stock
500 mg USD 144 In-stock
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Based on 1 publication(s) in Google Scholar

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Sparfloxacin Related Antibodies

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Description

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity[1].

IC50 & Target

Quinolone

 

In Vitro

Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice[1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sparfloxacin Related Antibodies
Molecular Weight

392.40

Formula

C19H22F2N4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CN(C2CC2)C3=C(C(N)=C(F)C(N4C[C@H](C)N[C@H](C)C4)=C3F)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

0.1 M NaOH : 50 mg/mL (127.42 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 5 mg/mL (12.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5484 mL 12.7421 mL 25.4842 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.93%

COA (250 KB) HNMR (255 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M NaOH 1 mM 2.5484 mL 12.7421 mL 25.4842 mL 63.7105 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL 12.7421 mL
10 mM 0.2548 mL 1.2742 mL 2.5484 mL 6.3711 mL
0.1 M NaOH 15 mM 0.1699 mL 0.8495 mL 1.6989 mL 4.2474 mL
20 mM 0.1274 mL 0.6371 mL 1.2742 mL 3.1855 mL
25 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
30 mM 0.0849 mL 0.4247 mL 0.8495 mL 2.1237 mL
40 mM 0.0637 mL 0.3186 mL 0.6371 mL 1.5928 mL
50 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
60 mM 0.0425 mL 0.2124 mL 0.4247 mL 1.0618 mL
80 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7964 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
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Sparfloxacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sparfloxacin110871-86-8CI-978 AT-4140CI978CI 978AT4140AT 4140AT-4140BacterialAntibioticInhibitorinhibitorinhibit

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