2. NF-κB
  3. NF-κB
  4. SPDZi1

SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin.

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SPDZi1 Chemical Structure

SPDZi1 Chemical Structure

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SPDZi1 Related Antibodies

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Description

SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin[1].

In Vitro

SPDZi1 (Z3322068027; 20 μM; 24 h) inhibits human glioblastoma multiforme (GBM) cell proliferation while concurrently reducing the activation of NF-κB[1].
In glioblastoma organoids (GBOs), SPDZi1 effectively suppresses the growth of small GBOs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPDZi1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U87-MG
Concentration: 20 μM
Incubation Time: 24 h
Result: Demonstrated a profound inhibitory effect on human GBM cell proliferation.
Molecular Weight

405.40

Formula

C22H19N3O5
SMILES

O=C(N[C@@H](CC(N1)=NC=CC1=O)C(O)=O)OCC(C2=C3C=CC=C2)C4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SPDZi1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPDZi1SPDZi 1SPDZi-1NF-κBNuclear factor-κBNuclear factor-kappaBMDA-9/Synteninglioblastoma multiformeInhibitorinhibitorinhibit

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