SphK1-IN-3 

SphK1-IN-3 is an effective sphingosine kinase-1 (SphK1) inhibitor. SphK1-IN-3 inhibits SphK1 kinase activity with an IC₅₀ value of 2.48 μM. SphK1-IN-3 can be used for the research of many diseases such as cancer, rheumatoid arthritis, diabetes, asthma, and pulmonary fibrosis^[1].

SphK1-IN-3 (Compound 47) efficiently inhibits SphK1 kinase activity with an IC₅₀ value of 2.48 μM^[1].
SphK1-IN-3 (0-31.1 µM) exhibits significant decrease in the fluorescence intensity of SphK1 as well as formed stable protein-ligand complexes^[1].
SphK1-IN-3 shows effective inhibitory potential toward SphK1 in enzyme inhibition assay^[1].
SphK1-IN-3 (10 µM) demonstrates effective antitumor activity and growth inhibitory potential toward cancer cell lines^[1].
SphK1-IN-3 fits well into the ATP-binding site of SphK1 and form significant hydrogen-bonding interactions with catalytically relevant residues as predicted by molecular docking^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

404.42

C₂₁H₂₀N₆O₃

O=[N+](C1=CC=C2NC(C3=C(N4CCOCC4)N(C5=CC=CC=C5)N=C3C)=NC2=C1)[O-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shadia A. Galal, et al. Design and synthesis of new pyrazolylbenzimidazoles as sphingosine kinase-1 inhibitors. Med Chem Res 30, 1614–1634 (2021).