2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphatase MDM-2/p53 Apoptosis
  4. SPI-001

SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis.

For research use only. We do not sell to patients.

SPI-001 Chemical Structure

SPI-001 Chemical Structure

CAS No. : 1220996-46-2

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SPI-001 Related Antibodies

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Description

SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis[1].

Molecular Weight

540.97

Formula

C30H60O4Si2
CAS No.
SMILES

C[C@H]1C[C@@H](O[Si](CC)(CC)CC)[C@]2([H])[C@@]([C@@](C[C@@H](O)C[C@]3(CO)C)(C)[C@]3([H])[C@@H](O[Si](C)(C(C)(C)C)C)C2)([H])C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SPI-001 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPI-0011220996-46-2SPI001SPI 001PhosphataseMDM-2/p53ApoptosisInhibitorAnticancerPhosphorylationProliferationinhibitorinhibit

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