Spinosyn A

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Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide.

For research use only. We do not sell to patients.

Spinosyn A Chemical Structure

CAS No. : 131929-60-7

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1 mg	USD 580	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Spinosyn A:

Spinosyn D Get quote
Spinosad Get quote
Spinosyn A (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	10.7 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30201293]
HCT-116	IC₅₀	11.1 μM Compound: 1	Antiproliferative activity against human HCT116 cells incubated for 48 hrs Antiproliferative activity against human HCT116 cells incubated for 48 hrs	[PMID: 32139325]
MCF7	IC₅₀	16.7 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30201293]
MCF7	IC₅₀	17.9 μM Compound: 1	Antiproliferative activity against human MCF7 cells incubated for 48 hrs Antiproliferative activity against human MCF7 cells incubated for 48 hrs	[PMID: 32139325]
NCI-H460	IC₅₀	66 μM Compound: 1	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 30201293]
NCI-H460	IC₅₀	67.5 μM Compound: 1	Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs	[PMID: 32139325]
U-87MG ATCC	IC₅₀	103.8 μM Compound: 1	Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay	[PMID: 30201293]
U-87MG ATCC	IC₅₀	96.5 μM Compound: 1	Antiproliferative activity against human U87MG cells incubated for 48 hrs Antiproliferative activity against human U87MG cells incubated for 48 hrs	[PMID: 32139325]

In Vitro

Spinosad is a mixture of two natural occurring macrocyclic lactones (spinosyn A and spinosyn D) and acts primarily as a nAChR agonist^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

731.96

Formula

C₄₁H₆₅NO₁₀

CAS No.

131929-60-7

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]([C@H](CCC[C@@H](O1)CC)O[C@@H]2O[C@@H]([C@H](CC2)N(C)C)C)C)C3=C[C@@]([C@](C=C[C@]4([H])C5)([H])[C@]3([H])CC1=O)([H])[C@]4([H])C[C@@H]5O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)OC)OC)OC

Structure Classification

Initial Source

Microorganisms

Saccharopolyspora spinosa

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (13.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3662 mL	6.8310 mL	13.6619 mL
5 mM	0.2732 mL	1.3662 mL	2.7324 mL
10 mM	0.1366 mL	0.6831 mL	1.3662 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hak Joong Kim, et al. Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK. J Am Chem Soc. 2010 Mar 10;132(9):2901-3. [Content Brief]

[2]. D T Vo, et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3662 mL	6.8310 mL	13.6619 mL	34.1549 mL
	5 mM	0.2732 mL	1.3662 mL	2.7324 mL	6.8310 mL
	10 mM	0.1366 mL	0.6831 mL	1.3662 mL	3.4155 mL

Spinosyn A Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spinosyn A131929-60-7Inhibitorinhibitorinhibit

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