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  4. Sporogen AO-1

Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity.

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Sporogen AO-1 Chemical Structure

Sporogen AO-1 Chemical Structure

CAS No. : 88418-12-6

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Based on 1 publication(s) in Google Scholar

Sporogen AO-1 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity[1].

Cellular Effect
Cell Line Type Value Description References
KB IC50
17.84 μM
Compound: 7
Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
[PMID: 25734623]
Vero IC50
4.23 μM
Compound: 7
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay
[PMID: 25734623]
Molecular Weight

248.32

Formula

C15H20O3
CAS No.
SMILES

CC([C@]1(C(C=C2CC[C@H]3O)=O)[C@]([C@@]2([C@H]3C)C)([H])O1)=C
Structure Classification
Initial Source

Aspergillus flavus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sporogen AO-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sporogen AO-188418-12-6Sporogen AO1Sporogen AO 1ParasiteAspergillus oryzaeplasmodium falciparum,antimalarialInhibitorinhibitorinhibit

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