SR-1277 

SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC₅₀s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC₅₀s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer^[1].

SR-1277 exhibits antiproliferative effects in A375 cells, with an EC₅₀ of 22 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR-1277 (1 mg/kg; i.v.) exhibits C_max (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM•h), T_1/2 (1.42 h) and brain penetration (24%) in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

477.50

C₂₁H₁₉N₉O₃S

1446715-47-4

O=[N+](C1=C2C(N=C(CNC3=C4N=CN(C5=CSC=C5)C4=NC(N6CCOCC6)=N3)N2)=CC=C1)[O-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bibian M, et, al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.  [Content Brief]