SR-16435

Cat. No.: HY-122681: FAQs
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SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid receptor partial agonist, with high binding affinity (NOP receptor K_i=7.49; μ-Opioid receptor K_i=2.70). SR-16435 can relieve pain.

For research use only. We do not sell to patients.

SR-16435 Chemical Structure

CAS No. : 857262-16-9

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•Related Small Molecules:

•Related Proteins:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

NOP receptor

7.49 (Ki)

μ-opioid

2.70 (Ki)

κ-opioid

219.47 (Ki)

In Vivo

SR 16435 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception^[1].
SR 16435 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20 to 25 g male ICR mice^[1]
Dosage:	10, 30 mg/kg
Administration:	s.c. for single-dose
Result:	Produced dose-dependent increase in tail-flick latency and induced antinociception.

Animal Model:	20 to 25 g male ICR mice^[1]
Dosage:	10, 30 mg/kg
Administration:	s.c. once daily for 9 days
Result:	Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.

Molecular Weight

338.49

Formula

C₂₂H₃₀N₂O

CAS No.

857262-16-9

SMILES

O=C1N(C2CCN(C3C4CCCC3CCC4)CC2)C5=C(C=CC=C5)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Khroyan TV, et al. SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice. J Pharmacol Exp Ther. 2007;320(2):934-943. [Content Brief]

SR-16435 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-16435857262-16-9SR16435SR 16435Opioid Receptorantinociceptionrattail flick latencydose-dependentbehaviorInhibitorinhibitorinhibit

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