2. Neuronal Signaling
  3. Dopamine Transporter Serotonin Transporter
  4. SRI-29574

SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT.

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SRI-29574 Chemical Structure

SRI-29574 Chemical Structure

CAS No. : 1928712-46-2

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Description

SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT[1].

Molecular Weight

441.53

Formula

C29H23N5
CAS No.
SMILES

C1(C2=CN3C(C=C2)=NC=C3)=NC(NCC(C4=CC=CC=C4)C5=CC=CC=C5)=C6C=CC=CC6=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SRI-29574 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRI-295741928712-46-2SRI29574SRI 29574Dopamine TransporterSerotonin TransporterDATSLC6A35-HTTSERTSLC6A4NETallosteric regulationprobeInhibitorinhibitorinhibit

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