2. Neuronal Signaling
  3. Dopamine Transporter
  4. SRI-31142

SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine.

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SRI-31142 Chemical Structure

SRI-31142 Chemical Structure

CAS No. : 1940118-04-6

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Description

SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine[1].

Molecular Weight

456.54

Formula

C29H24N6
CAS No.
SMILES

CC1=CC2=NC=CN2C=C1C3=NC(NCC(C4=CC=CC=C4)C5=CC=NC=C5)=C6C=CC=CC6=N3
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SRI-31142 Related Classifications

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Keywords:

SRI-311421940118-04-6SRI31142SRI 31142Dopamine TransporterDATSLC6A3Inhibitorinhibitorinhibit

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