2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. SSR 146977

SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM.

For research use only. We do not sell to patients.

SSR 146977 Chemical Structure

SSR 146977 Chemical Structure

CAS No. : 264618-44-2

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SSR 146977 Related Antibodies

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Description

SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM[1].

IC50 & Target[1]

NK3

 

Molecular Weight

621.64

Formula

C35H42Cl2N4O2
CAS No.
SMILES

O=C(N(C)C)NC1(CCN(CC1)CCC[C@]2(CN(CCC2)C(C3=CC=CC=C3)=O)C4=CC=C(C(Cl)=C4)Cl)C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SSR 146977 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SSR 146977264618-44-2SSR146977SSR-146977Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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