2. Metabolic Enzyme/Protease
  3. FXR
  4. ST-1892

ST-1892 (compound 14) is a highly potent FXR agonist (EC50=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation.

For research use only. We do not sell to patients.

ST-1892 Chemical Structure

ST-1892 Chemical Structure

CAS No. : 1409411-32-0

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ST-1892 Related Antibodies

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Description

ST-1892 (compound 14) is a highly potent FXR agonist (EC50=7.2 nM) that can be used to study diseases or disorders caused by metabolic inflammation[1].

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
0.0072 μM
Compound: 14
Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay
Agonist activity at human full length FXR expressed in HeLa cells cotransfected with pSG5-human RXR after 24 hrs by Dual-Glo luciferase reporter gene assay
[PMID: 25934227]
Molecular Weight

280.28

Formula

C16H12N2O3
CAS No.
SMILES

O=C(C1=CC=CC(C2=NC(C3=CC=CC=C3C)=NO2)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ST-1892 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-18921409411-32-0ST1892ST 1892FXRNR1H4High potencyagonistmetabolic diseasesinflammationInhibitorinhibitorinhibit

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HY-117918
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