STAT3 degrader-2 

STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases^[1]. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

STAT3 degrader-2 (Compound 92) (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM; 3 h) decreased the level of total STAT3 protein in acute leukemia Molm-16 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3 degrader-2 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) decreased the level of total STAT3 protein and phosphorylated STAT3 (Y705) protein in acute leukemia Molm-16 tumors and SU-DHL-1 tumors in mice^[1].
STAT3 degrader-2 (i.v.; 25, 50 mg/kg; qw) shows antitumor activity against Molm-16 xenograft tumors in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1136.15

C₅₉H₆₂N₉O₁₃P

2497583-03-4

O=C(N1C[C@@H](C(N2[C@@](CC[C@H]2C(N[C@@H](CCC(N)=O)C(NC(C3=CC=CC=C3)C4=CC=CC=C4)=O)=O)([H])CC1)=O)NC(C5=CC6=CC(C(P(O)(O)=O)=O)=CC=C6N5)=O)CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shaomeng Wang, et al. Small molecule degraders of stat3. Patent. WO2020198435A1.