STAT3-IN-9 

STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase^[1].

STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC₅₀s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively^[1].
STAT3-IN-9 (0, 0.2, 1.0, 5.0 µM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701)^[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway^[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

391.42

C₂₂H₂₁N₃O₄

2987726-27-0

COC1=CC(NC2=CC(C3=CC=NN3C)=CC4=C2OC(C(C)=O)=C4)=CC(OC)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang F, et al. Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study. Bioorg Med Chem. 2020; 28(24):115822.  [Content Brief]