Stercobilin hydrochloride (mixture of isomers) 

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections^[1][2].

631.20

C₃₃H₄₇ClN₄O₆

13129-80-1

OC(CCC(C(C)=C(N1)C[C@H]2[C@@H]([C@H](C(N2)=O)C)CC)=C1/C=C3C(CCC(O)=O)=C(C(C[C@H]4[C@@H]([C@H](C(N4)=O)CC)C)=N/3)C)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sanada S, et al. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep. 2020 Apr 15;10(1):6479.  [Content Brief]

  [2]. McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. Biochem J. 1996 Dec 1;320 ( Pt 2)(Pt 2):681-6.  [Content Brief]