Steroid sulfatase/17β-HSD1-IN-3 

Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC₅₀ value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases^[1].

IC50: 27 nM (hSTS)^[1].

Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC₅₀ value of 27 nM and acts on irreversible inhibition of hSTS with an IC₅₀ value of 29 nM in T47D human breast cancer cells^[1].
Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (20 μM, 48 h) inhibits HEK-293 cells growth by 30% at a concentration of 20 μM with low cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

420.87

C₁₉H₁₇ClN₂O₅S

2990549-76-1

O=S(OC1=CC=C(C2=CC=C(C(N(C)C3=CC=CC=C3C)=O)O2)C(Cl)=C1)(N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Abdelrahman Mohamed, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22.  [Content Brief]