1. Anti-infection
  2. Fungal
  3. Stilbamidine dihydrochloride

Stilbamidine dihydrochloride  (Synonyms: Ba 2652 dihydrochloride; Stilbamidin dihydrochloride)

Cat. No.: HY-U00007A Purity: 95.44%
Data Sheet SDS COA Handling Instructions

Stilbamidine dihydrochloride is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.

For research use only. We do not sell to patients.

Stilbamidine dihydrochloride Chemical Structure

Stilbamidine dihydrochloride Chemical Structure

CAS No. : 6935-63-3

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Stilbamidine dihydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Stilbamidine dihydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Stilbamidine dihydrochloride is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.

In Vitro

The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine dihydrochloride. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine dihydrochloride, and Propamidine. [3H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC50=1.2 μM) or melarsen oxide (IC50=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC50=6.1 μM) and Stilbamidine dihydrochloride (IC50=110 μM)[1]. The two diamidine compounds, Stilbamidine dihydrochloride and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

337.25

Formula

C16H18Cl2N4

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N=C(N)C1=CC=C(C=C1)/C=C/C2=CC=C(C=C2)C(N)=N.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 1.96 mg/mL (5.81 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9652 mL 14.8258 mL 29.6516 mL
5 mM 0.5930 mL 2.9652 mL 5.9303 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9652 mL 14.8258 mL 29.6516 mL 74.1290 mL
5 mM 0.5930 mL 2.9652 mL 5.9303 mL 14.8258 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Stilbamidine dihydrochloride
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