2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. STIMA-1

STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells.

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STIMA-1 Chemical Structure

STIMA-1 Chemical Structure

CAS No. : 91634-12-7

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50 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

STIMA-1 Related Antibodies

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Description

STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells[1].

Molecular Weight

172.18

Formula

C10H8N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C=C)=NC2=C1C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1451.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8079 mL 29.0394 mL 58.0788 mL
5 mM 1.1616 mL 5.8079 mL 11.6158 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8079 mL 29.0394 mL 58.0788 mL 145.1969 mL
5 mM 1.1616 mL 5.8079 mL 11.6158 mL 29.0394 mL
10 mM 0.5808 mL 2.9039 mL 5.8079 mL 14.5197 mL
15 mM 0.3872 mL 1.9360 mL 3.8719 mL 9.6798 mL
20 mM 0.2904 mL 1.4520 mL 2.9039 mL 7.2598 mL
25 mM 0.2323 mL 1.1616 mL 2.3232 mL 5.8079 mL
30 mM 0.1936 mL 0.9680 mL 1.9360 mL 4.8399 mL
40 mM 0.1452 mL 0.7260 mL 1.4520 mL 3.6299 mL
50 mM 0.1162 mL 0.5808 mL 1.1616 mL 2.9039 mL
60 mM 0.0968 mL 0.4840 mL 0.9680 mL 2.4199 mL
80 mM 0.0726 mL 0.3630 mL 0.7260 mL 1.8150 mL
100 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.4520 mL
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STIMA-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STIMA-191634-12-7STIMA1STIMA 1MDM-2/p53Apoptosisactive compoundp53proliferationdifferentiationkeratinocytesInhibitorinhibitorinhibit

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