2. PROTAC Immunology/Inflammation
  3. PROTACs STING
  4. STING-IN-10

STING-IN-10 (P8) is a dual STING PROTAC degrader and inhibitor with a DC50 value of 2.58 μM in THP-1 cells. STING-IN-10 has anti-inflammatory activity.(Pink: Target protein ligand (HY-168676); Black: linker (HY-168675); Blue: E3 ligase ligand (HY-W039116))

For research use only. We do not sell to patients.

STING-IN-10 Chemical Structure

STING-IN-10 Chemical Structure

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STING-IN-10 Related Antibodies

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Description

STING-IN-10 (P8) is a dual STING PROTAC degrader and inhibitor with a DC50 value of 2.58 μM in THP-1 cells. STING-IN-10 has anti-inflammatory activity[1].(Pink: Target protein ligand (HY-168676); Black: linker (HY-168675); Blue: E3 ligase ligand (HY-W039116))

Molecular Weight

727.68

Formula

C35H33N7O11
SMILES

O=C1CCC(C(N1)=O)N2C(C3=CC=CC(OCC4=CN(N=N4)CCCCCC(OCCC5=CC=C(C=C5)NC(C6=CC=C(O6)[N+]([O-])=O)=O)=O)=C3C2=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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STING-IN-10 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING-IN-10PROTACsSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSDegraderTHP-1RAW264.7anti-inflammatoryInhibitorinhibitorinhibit

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STING-IN-10
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HY-168554
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