Substance P (3-11) 

Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis ^[1][2][5].

Substance P (3-11) permeates the BBMEC monolayers with permeation rate (cm/s) of 1.92 x 10^5[2].
Substance P (3-11) promotes human monocyte chemotaxis in a modified Boyden chamber assay^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Substance P (3-11) (30 nmol/kg, i.v. infusion) increases plasma histamine in rats^[4]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1094.33

C₅₂H₇₉N₁₃O₁₁S

51165-11-8

KPQQFFGLM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72(4 Pt.2):803-10.  [Content Brief]

  [2]. Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23(6):1201-8.  [Content Brief]

  [3]. Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11.  [Content Brief]

  [4]. Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138(1):151-9.  [Content Brief]

  [5]. Freed AL, et al. Investigation of substance P transport across the blood-brain barrier. Peptides. 2002 Jan;23(1):157-65.  [Content Brief]