2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation Apoptosis
  3. p38 MAPK ERK JNK Interleukin Related TNF Receptor
  4. Sugiol

Sugiol  (Synonyms: (+)-Sugiol; 10-Deoxoxanthoperol)

Cat. No.: HY-N1195
Handling Instructions

Molarity Calculator

Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages.

For research use only. We do not sell to patients.

Sugiol Chemical Structure

Sugiol Chemical Structure

CAS No. : 511-05-7

Size Price Stock Quantity
1 mg USD 380 Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
5 mg USD 940 Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
10 mg   Get quote  
50 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Sugiol Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].

IC50 & Target[1]

ERK1

 

ERK2

 

p38 MAPK

 

JNK1

 

JNK2

 

IL-1β

 

In Vitro

Sugiol (5-30 μM; 30 min) inhibits TNF-α and proIL-1β/IL-1β protein production in J774A.1 cells[1].
Sugiol (5-30 μM; 30 min) inhibits MAPK activation, suppresses ERK1/2, JUNK1/2, and p38 phosphorylation in LPS-induced J774A.1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sugiol Related Antibodies

Western Blot Analysis[1]

Cell Line: J774A.1 macrophages cells stimulated with LPS
Concentration: 5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time: 30 min
Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
Molecular Weight

300.44

Formula

C20H28O2
CAS No.
SMILES

O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Sugiol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sugiol511-05-7(+)-Sugiol 10-Deoxoxanthoperolp38 MAPKERKJNKInterleukin RelatedTNF ReceptorExtracellular signal regulated kinasesc-Jun N-terminal kinaseILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Sugiol
Cat. No.:
HY-N1195
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.