2. MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation Apoptosis
  3. p38 MAPK ERK JNK Interleukin Related TNF Receptor
  4. Sugiol

Sugiol  (Synonyms: (+)-Sugiol; 10-Deoxoxanthoperol)

Cat. No.: HY-N1195
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Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages.

For research use only. We do not sell to patients.

Sugiol Chemical Structure

Sugiol Chemical Structure

CAS No. : 511-05-7

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Based on 1 publication(s) in Google Scholar

Sugiol Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].

IC50 & Target[1]

ERK1

 

ERK2

 

p38 MAPK

 

JNK1

 

JNK2

 

IL-1β

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
A549 GI50
79.8 μM
Compound: 13
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
BEAS-2B IC50
> 10 μM
Compound: 17
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
BXPC-3 GI50
36.08 μM
Compound: 13
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
HL-60 IC50
> 10 μM
Compound: 17
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
HL-60 GI50
68.64 μM
Compound: 13
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
K562 IC50
6.7 μM
Compound: Sugiol
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 30684866]
MCF7 IC50
> 10 μM
Compound: 17
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
MIA PaCa-2 IC50
17.9 μM
Compound: 10
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
[PMID: 21775156]
MRC5 GI50
> 100 μM
Compound: 13
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PANC-1 GI50
87.94 μM
Compound: 13
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
PC-3 GI50
> 100 μM
Compound: 13
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
[PMID: 24210499]
SMMC-7721 IC50
> 10 μM
Compound: 17
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
SW480 IC50
> 10 μM
Compound: 17
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
[PMID: 33978415]
Vero IC50
45.4 μM
Compound: 2
Cytotoxicity against african green monkey Vero cells after 72 hrs
Cytotoxicity against african green monkey Vero cells after 72 hrs
[PMID: 25462275]
In Vitro

Sugiol (5-30 μM; 30 min) inhibits TNF-α and proIL-1β/IL-1β protein production in J774A.1 cells[1].
Sugiol (5-30 μM; 30 min) inhibits MAPK activation, suppresses ERK1/2, JUNK1/2, and p38 phosphorylation in LPS-induced J774A.1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sugiol Related Antibodies

Western Blot Analysis[1]

Cell Line: J774A.1 macrophages cells stimulated with LPS
Concentration: 5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time: 30 min
Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
Molecular Weight

300.44

Formula

C20H28O2
CAS No.
SMILES

O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sugiol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sugiol511-05-7(+)-Sugiol 10-Deoxoxanthoperolp38 MAPKERKJNKInterleukin RelatedTNF ReceptorExtracellular signal regulated kinasesc-Jun N-terminal kinaseILTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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