2. PROTAC
  3. PROTAC Linkers
  4. Sulfo DBCO-PEG4-amine

Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Sulfo DBCO-PEG4-amine Chemical Structure

Sulfo DBCO-PEG4-amine Chemical Structure

CAS No. : 2055198-05-3

Size Price Stock Quantity
5 mg USD 140 In-stock
10 mg USD 230 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Sulfo DBCO-PEG4-amine Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfo DBCO-PEG4-amine Related Antibodies
Molecular Weight

674.76

Formula

C32H42N4O10S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CCOCCOCCOCCOCCN)NCC(S(=O)(O)=O)C(NCCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (148.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4820 mL 7.4100 mL 14.8201 mL
5 mM 0.2964 mL 1.4820 mL 2.9640 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4820 mL 7.4100 mL 14.8201 mL 37.0502 mL
5 mM 0.2964 mL 1.4820 mL 2.9640 mL 7.4100 mL
10 mM 0.1482 mL 0.7410 mL 1.4820 mL 3.7050 mL
15 mM 0.0988 mL 0.4940 mL 0.9880 mL 2.4700 mL
20 mM 0.0741 mL 0.3705 mL 0.7410 mL 1.8525 mL
25 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.4820 mL
30 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2350 mL
40 mM 0.0371 mL 0.1853 mL 0.3705 mL 0.9263 mL
50 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7410 mL
60 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6175 mL
80 mM 0.0185 mL 0.0926 mL 0.1853 mL 0.4631 mL
100 mM 0.0148 mL 0.0741 mL 0.1482 mL 0.3705 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Sulfo DBCO-PEG4-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfo DBCO-PEG4-amine2055198-05-3PROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Sulfo DBCO-PEG4-amine
Cat. No.:
HY-140286
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.