2. PROTAC
  3. PROTAC Linkers
  4. Sulfo DBCO-PEG4-amine

Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Sulfo DBCO-PEG4-amine Chemical Structure

Sulfo DBCO-PEG4-amine Chemical Structure

CAS No. : 2055198-05-3

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5 mg USD 140 In-stock
10 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

Sulfo DBCO-PEG4-amine Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

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Description

Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfo DBCO-PEG4-amine Related Antibodies
Molecular Weight

674.76

Formula

C32H42N4O10S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CCOCCOCCOCCOCCN)NCC(S(=O)(O)=O)C(NCCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (148.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4820 mL 7.4100 mL 14.8201 mL
5 mM 0.2964 mL 1.4820 mL 2.9640 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4820 mL 7.4100 mL 14.8201 mL 37.0502 mL
5 mM 0.2964 mL 1.4820 mL 2.9640 mL 7.4100 mL
10 mM 0.1482 mL 0.7410 mL 1.4820 mL 3.7050 mL
15 mM 0.0988 mL 0.4940 mL 0.9880 mL 2.4700 mL
20 mM 0.0741 mL 0.3705 mL 0.7410 mL 1.8525 mL
25 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.4820 mL
30 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2350 mL
40 mM 0.0371 mL 0.1853 mL 0.3705 mL 0.9263 mL
50 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7410 mL
60 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6175 mL
80 mM 0.0185 mL 0.0926 mL 0.1853 mL 0.4631 mL
100 mM 0.0148 mL 0.0741 mL 0.1482 mL 0.3705 mL
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Sulfo DBCO-PEG4-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfo DBCO-PEG4-amine2055198-05-3PROTAC LinkersInhibitorinhibitorinhibit

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