2. GPCR/G Protein Others Neuronal Signaling
  3. 5-HT Receptor Isotope-Labeled Compounds
  4. Sumatriptan-d6 succinate

Sumatriptan-d6 succinate  (Synonyms: GR 43175C-d6)

Cat. No.: HY-B0121BS Purity: 99.63%
SDS COA Handling Instructions

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Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research.

For research use only. We do not sell to patients.

Sumatriptan-d<sub>6</sub> succinate Chemical Structure

Sumatriptan-d6 succinate Chemical Structure

CAS No. : 1215621-31-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Sumatriptan-d6 succinate:

Sumatriptan-d6 succinate Related Antibodies

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Description

Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sumatriptan-d6 succinate Related Antibodies
Molecular Weight

419.53

Formula

C18H21D6N3O6S
CAS No.
Unlabeled CAS

103628-48-4
Appearance

Solid

Color

White to off-white

SMILES

OC(CCCC(CC(O)=O)C(O)=O.C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])C=1C=2C(NC1)=CC=C(CS(NC)(=O)=O)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (238.36 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3836 mL 11.9181 mL 23.8362 mL
5 mM 0.4767 mL 2.3836 mL 4.7672 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.63%

SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3836 mL 11.9181 mL 23.8362 mL 59.5905 mL
5 mM 0.4767 mL 2.3836 mL 4.7672 mL 11.9181 mL
10 mM 0.2384 mL 1.1918 mL 2.3836 mL 5.9590 mL
15 mM 0.1589 mL 0.7945 mL 1.5891 mL 3.9727 mL
20 mM 0.1192 mL 0.5959 mL 1.1918 mL 2.9795 mL
25 mM 0.0953 mL 0.4767 mL 0.9534 mL 2.3836 mL
30 mM 0.0795 mL 0.3973 mL 0.7945 mL 1.9863 mL
40 mM 0.0596 mL 0.2980 mL 0.5959 mL 1.4898 mL
50 mM 0.0477 mL 0.2384 mL 0.4767 mL 1.1918 mL
60 mM 0.0397 mL 0.1986 mL 0.3973 mL 0.9932 mL
80 mM 0.0298 mL 0.1490 mL 0.2980 mL 0.7449 mL
100 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.5959 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sumatriptan-d6 succinate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sumatriptan-d61215621-31-0GR 43175C-d65-HT ReceptorIsotope-Labeled CompoundsSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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