T-1101 (Synonyms: TAI-95)

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T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI₅₀ of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.

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T-1101 Chemical Structure

CAS No. : 1438638-83-5

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Other Forms of T-1101:

T-1101-d₇ Get quote
T-1101 tosylate Get quote

1 Publications Citing Use of MCE T-1101

•Cancer Res Commun. 2024 Apr 9;4(4):1024-1040. [Abstract]

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•Related Small Molecules:

•Related Proteins:

View All NEKs Isoform Specific Products:

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NEK1 NEK2 NEK6 NEK7

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NEK2

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	GI₅₀	29.1 nM Compound: 9j	Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
HeLa	IC₅₀	21.1 nM Compound: 9j	Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
Huh-7	GI₅₀	34.98 nM Compound: 9j	Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
Huh-7	GI₅₀	59.9 nM Compound: 9j	Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
K562	IC₅₀	18 nM Compound: 9j	Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
MDA-MB-231	IC₅₀	14.8 nM Compound: 9j	Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
MDA-MB-468	IC₅₀	21.5 nM Compound: 9j	Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
U2OS	GI₅₀	83.2 nM Compound: 9j	Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]
U-937	GI₅₀	12.4 nM Compound: 9j	Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay	[PMID: 32113126]

Molecular Weight

493.60

Formula

C₂₄H₂₃N₅O₃S₂

CAS No.

1438638-83-5

SMILES

O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang LY, et al., Inhibition of Hec1 as a novel approach for treatment of primary liver cancer. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20. [Content Brief]

T-1101 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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