2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis NEKs
  4. T-1101

T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.

For research use only. We do not sell to patients.

T-1101 Chemical Structure

T-1101 Chemical Structure

CAS No. : 1438638-83-5

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T-1101 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE T-1101

View All NEKs Isoform Specific Products:

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NEK1 NEK2 NEK6 NEK7

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Description

T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models[1].

IC50 & Target

NEK2

 

Molecular Weight

493.60

Formula

C24H23N5O3S2
CAS No.
SMILES

O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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T-1101 Related Classifications

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-11011438638-83-5TAI-95T1101T 1101TAI95TAI 95ApoptosisNEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed Kinasesprimary liver cancerHCChepatoblastomaHuh-7HepG2WI-38HUVECRPTECHep3BJHHSNUSCID mouseorally activeInhibitorinhibitorinhibit

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