2. Anti-infection
  3. Fungal
  4. T-2307

T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .

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T-2307 Chemical Structure

T-2307 Chemical Structure

CAS No. : 873546-31-7

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Based on 1 publication(s) in Google Scholar

T-2307 Related Antibodies

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Description

T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) [1].

In Vitro

T-2307 exhibits potent activity against fluconazole-resistant and fluconazole-susceptible-dose-dependent Candida albicans strains as well as against azole-susceptible strains[1].
T-2307 shows efficacy in a murine model of candida glabrata infection despite in vitro trailing growth phenomena[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T-2307 Related Antibodies

Cell Viability Assay[2]

Cell Line: C. glabrata ATCC 90030
Concentration: 0.000125, 0.00025, 0.0005, 0.001, 0.002, 0.0039, 0.0078, 0.0156, 0.0313, 0.0625, 0.125 μg/mL
Incubation Time: 24 and 48 hours
Result: C. glabrata exhibited significant trailing growth at concentrations between 0.0039 and 0.125 μg/mL at 48 h.
The trailing growth of C. glabrata at 24 h of incubation was similar to that at 48 h.
In Vivo

In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the ED50 of T-2307 were 0.00755, 0.117, and 0.391 mg/kg, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old specific-pathogen-free ICR strain male mice bearing systemic infections with Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus[1].
Dosage: 0.001, 0.1, 1 mg/kg
Administration: Subcutaneously administered; once a day for 7 days, beginning at 2 h after the infection.
Result: In the systemic infection caused by Candida albicans, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 0.01 mg/kg compared with that in the control mice. The calculated ED50s of T-2307were 0.00755 mg/kg.
In the systemic infection caused by Cryptococcus neoformans, all the control mice died by day 9. Mortality was significantly delayed in mice administered T-2307 at a dose of 0.1 mg/kg compared with that in the control mice. The calculated ED50s of T-2307 were 0.117 mg/kg.
In the systemic infection caused by Aspergillus fumigatus, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 1 mg/kg compared with that in the control mice. The calculated ED50s of T-2307 were 0.391 mg/kg.
Molecular Weight

437.58

Formula

C25H35N5O2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

N=C(C1=CC=C(OCCCN2CCC(CCCOC3=CC=C(C(N)=N)C=C3)CC2)C=C1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (114.26 mM; ultrasonic and adjust pH to 3 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2853 mL 11.4265 mL 22.8530 mL
5 mM 0.4571 mL 2.2853 mL 4.5706 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.41%

SDS (251 KB)

COA (242 KB) HNMR (148 KB) RP-HPLC (169 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2853 mL 11.4265 mL 22.8530 mL 57.1324 mL
5 mM 0.4571 mL 2.2853 mL 4.5706 mL 11.4265 mL
10 mM 0.2285 mL 1.1426 mL 2.2853 mL 5.7132 mL
15 mM 0.1524 mL 0.7618 mL 1.5235 mL 3.8088 mL
20 mM 0.1143 mL 0.5713 mL 1.1426 mL 2.8566 mL
25 mM 0.0914 mL 0.4571 mL 0.9141 mL 2.2853 mL
30 mM 0.0762 mL 0.3809 mL 0.7618 mL 1.9044 mL
40 mM 0.0571 mL 0.2857 mL 0.5713 mL 1.4283 mL
50 mM 0.0457 mL 0.2285 mL 0.4571 mL 1.1426 mL
60 mM 0.0381 mL 0.1904 mL 0.3809 mL 0.9522 mL
80 mM 0.0286 mL 0.1428 mL 0.2857 mL 0.7142 mL
100 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL
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T-2307 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-2307873546-31-7T2307T 2307FungalarylamidineantifungalbroadspectrumCandidaCryptococcusneoformansAspergillusInhibitorinhibitorinhibit

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