2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. LXR FXR ROR Apoptosis
  4. T0901317 (Standard)

T0901317 (Standard) is the analytical standard of T0901317. This product is intended for research and analytical applications. T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα[1]. T0901317 activates FXR with an EC50 of 5 μM[2]. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively[3]. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice[4][5].

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T0901317 (Standard) Chemical Structure

T0901317 (Standard) Chemical Structure

CAS No. : 293754-55-9

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Description

T0901317 (Standard) is the analytical standard of T0901317. This product is intended for research and analytical applications. T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα[1]. T0901317 activates FXR with an EC50 of 5 μM[2]. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively[3]. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice[4][5].

Molecular Weight

481.33

Formula

C17H12F9NO3S
CAS No.
SMILES

OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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T0901317 (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

T0901317 (Standard)293754-55-9LXRFXRRORApoptosisLiver X receptorNR1H4RAR-related orphan receptororallyLXRαLXRβRORαRORγatherosclerosisLDLCaOV3SKOV3A2780ovariancarcinomaHS-68foreskinfibroblastsInhibitorinhibitorinhibit

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