2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. T5342126

T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

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T5342126 Chemical Structure

T5342126 Chemical Structure

CAS No. : 956507-49-6

Size Price Stock Quantity
Solvent
1 mg (21.83 mM * 100 μL in Methyl acetate) In-stock
Solvent
5 mg (21.83 mM * 500 μL in Methyl acetate) In-stock
Solvent
10 mg (21.83 mM * 1 mL in Methyl acetate) In-stock
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Based on 1 publication(s) in Google Scholar

T5342126 Related Antibodies

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1 Publications Citing Use of MCE T5342126

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Description

T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
27.8 μM
Compound: 1j
Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrs
Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrs
[PMID: 21591694]
Molecular Weight

457.99

Formula

C25H32ClN3O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(COC1=CC=C(OCC)C=C1)CN(CC2=C(C)N(CC3=CC=CC=C3Cl)N=C2C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 98.1%

SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References
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T5342126 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T5342126956507-49-6T 5342126T-5342126Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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