T988C  (Synonyms: (+)-T988C)

T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells^[1].

T988C inhibits P388 leukemia cells with an ID₅₀ value of 0.56 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

480.56

C₂₃H₂₀N₄O₄S₂

823802-57-9

O[C@H]1[C@@]2(C3=CNC4=CC=CC=C34)[C@@](NC5=CC=CC=C52)([H])N6[C@@]17C(N([C@](C6=O)(SS7)CO)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. DeLorbe JE, et al. General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A. J Am Chem Soc. 2013 Mar 13;135(10):4117-28.  [Content Brief]

  [2]. Feng Y, et al. Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp. J Nat Prod. 2004 Dec;67(12):2090-2.  [Content Brief]