Taccalonolide E

Cat. No.: HY-N11067: FAQs
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Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.

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Taccalonolide E Chemical Structure

CAS No. : 134954-57-7

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Description

Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	39.5 μM Compound: Taccalonolide E	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 23855953]
HeLa	IC₅₀	39500 nM Compound: 7	Antiproliferative activity against human HeLa cells by SRB assay Antiproliferative activity against human HeLa cells by SRB assay	[PMID: 24959756]
HeLa	IC₅₀	644 nM Compound: 3	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 21800839]

In Vitro

Taccalonolide E (5 or 10 μM; 18 h) causes an increased density of cellular microtubules in interphase cells and the formation of thick bundles of microtubules in A-10 cells^[1].
Taccalonolide E (1 or 5 μM; 18 h) causes the appearance of abnormal multipolar mitotic spindles in A-10 and HeLa cells^[1].
Taccalonolide E (5 μM; 6-24 h) arrests cell cycle at G2-M phase^[1].
Taccalonolide E (0.5-5 μM; 18 h) initiates micronucleation in interphase A-10 cells^[1].
Taccalonolide E (48 h) inhibits cancer cell proliferation^[1].
Taccalonolide E (10 μM; 1 h) causes polymerization of tubulin in MDA-MB-435 cells^[1].
Taccalonolide E (5 μM; 4-30 h) initiates Bcl-2 phosphorylation, MAPK activation, and apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MDA-MB-435 cells
Concentration:	5 μM
Incubation Time:	6, 12, 18, or 24 h
Result:	Caused cells to accumulate in the G2-M phase of the cell cycle.

Cell Proliferation Assay^[1]

Cell Line:	SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells
Concentration:
Incubation Time:	48 h
Result:	Inhibited the proliferation with IC₅₀s of 0.99 ± 0.08, 0.78 ± 0.17, 21.1 ± 0.46, 0.34 ± 0.04, 1.64 ± 0.25, 4.01 ± 0.20 and 1.42 ± 0.30 μM against SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells, respectively.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-435 cells
Concentration:	5 μM
Incubation Time:	4, 6, 12, 24, or 30 h
Result:	Activated ERK1/2 and increased PARP cleavage.

Molecular Weight

644.71

Formula

C₃₄H₄₄O₁₂

CAS No.

134954-57-7

SMILES

CC(O[C@H]1[C@]2([H])[C@@]([C@@H](C=C3[C@@]2([C@](O)(C(O3)=O)C)C)C)([H])[C@@]4([C@]1([H])[C@@]5([H])[C@]([C@]6([C@H]([C@]7([H])[C@](O7)([H])C[C@]6([H])C([C@@H]5O)=O)OC(C)=O)C)([H])C[C@@H]4OC(C)=O)C)=O

Structure Classification

Steroids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tinley TL, et al. Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20. [Content Brief]

Taccalonolide E Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taccalonolide E134954-57-7ApoptosisA-10Bcl-2 phosphorylationMAPKMDA-MB-435Inhibitorinhibitorinhibit

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