2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Autophagy Apoptosis Immunology/Inflammation Anti-infection
  3. Phosphatase FKBP Bacterial Autophagy Antibiotic
  4. Tacrolimus-13C,d2

Tacrolimus-13C,d2  (Synonyms: FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2)

Cat. No.: HY-13756S Purity: 98.36%
COA Handling Instructions

Molarity Calculator

Tacrolimus-13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

For research use only. We do not sell to patients.

Tacrolimus-<sup>13</sup>C,d<sub>2</sub> Chemical Structure

Tacrolimus-13C,d2 Chemical Structure

CAS No. : 1356841-89-8

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1 mg USD 1420 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tacrolimus-13C,d2:

Tacrolimus-13C,d2 Related Antibodies

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Description

Tacrolimus-13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

IC50 & Target

Macrolide

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tacrolimus-13C,d2 Related Antibodies
Molecular Weight

807.02

Formula

C4313CH67D2NO12
CAS No.
Unlabeled CAS

104987-11-3
Appearance

Solid

Color

White to yellow

SMILES

O=C(O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(C)=C/[C@H]2C[C@H]([C@@H](CC2)O)OC)[C@]3([H])CCCCN3C(C([C@]4([C@@H](C[C@@H]([C@@]([H])([C@H](C[C@H](C/C(C)=C/[C@H]1C/C=[13C]([2H])\[2H])C)OC)O4)OC)C)O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 30 mg/mL (37.17 mM)

Ethanol : ≥ 30 mg/mL (37.17 mM)

DMF : ≥ 30 mg/mL (37.17 mM)

Ethanol : ≥ 30 mg/mL (37.17 mM)

DMSO : ≥ 20 mg/mL (24.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 20 mg/mL (24.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2391 mL 6.1956 mL 12.3913 mL
5 mM 0.2478 mL 1.2391 mL 2.4783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.36%

COA (261 KB) HNMR (133 KB) RP-HPLC (100 KB) MS (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO / DMF / Ethanol / DMF / Ethanol 1 mM 1.2391 mL 6.1956 mL 12.3913 mL 30.9782 mL
5 mM 0.2478 mL 1.2391 mL 2.4783 mL 6.1956 mL
10 mM 0.1239 mL 0.6196 mL 1.2391 mL 3.0978 mL
15 mM 0.0826 mL 0.4130 mL 0.8261 mL 2.0652 mL
20 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5489 mL
DMF / Ethanol / DMF / Ethanol 25 mM 0.0496 mL 0.2478 mL 0.4957 mL 1.2391 mL
30 mM 0.0413 mL 0.2065 mL 0.4130 mL 1.0326 mL
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Tacrolimus-13C,d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tacrolimus-13C,d21356841-89-8FK506-13C,d2Fujimycin-13C,d2FR900506-13C,d2PhosphataseFKBPBacterialAutophagyAntibioticFK506-binding proteinInhibitorinhibitorinhibit

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