2. MAPK/ERK Pathway GPCR/G Protein Others
  3. Ras Others
  4. Tadnersen

Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Tadnersen sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

RNA, ([2′-O-(2-methoxyethyl)]G-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-sp-m5dC-sp-dT-sp-dA-sp-dG-sp-m5dC-sp-dG-sp-m5dC-sp-dG-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]G-[2′-O-(2-methoxyethyl)]A-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5U-sp-[2′-O-(2-methoxyethyl)]m5C) (ACI)

Tadnersen Chemical Structure

CAS No. : 2170507-65-8

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Description

Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion[1].

In Vitro

Tadnersen (BIIB078) is an RNAse H oligomer that selectively inhibits mutant C9ORF72 transcripts. Tadnersen is used for the research of Amyotrophic Lateral Sclerosis (ALS)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tadnersen Related Antibodies
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, ([2′-O-(2-methoxyethyl)]G-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-sp-m5dC-sp-dT-sp-dA-sp-dG-sp-m5dC-sp-dG-sp-m5dC-sp-dG-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]G-[2′-O-(2-methoxyethyl)]A-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5U-sp-[2′-O-(2-methoxyethyl)]m5C) (ACI)
SMILES

[Tadnersen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tadnersen2170507-65-8BIIB078 IONIS-C9RxBIIB 078BIIB-078RasOthersAmyotrophicLateralSclerosisALSC9ORF72transcriptsantisenseoligonucleotideInhibitorinhibitorinhibit

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