2. NF-κB MAPK/ERK Pathway Immunology/Inflammation Apoptosis
  3. NF-κB p38 MAPK Interleukin Related TNF Receptor NO Synthase COX
  4. Talaromyketide B

Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases.

For research use only. We do not sell to patients.

Talaromyketide B Chemical Structure

Talaromyketide B Chemical Structure

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Talaromyketide B Related Antibodies

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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Description

Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases[1].

Molecular Weight

292.28

Formula

C15H16O6
SMILES

O=C1C2=CC(OC)=CC(O)=C2C(C(OCC)=O)(O)C=C1C
Structure Classification
Initial Source

Talaromyces sp. KYS-41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Talaromyketide B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talaromyketide BNF-κBp38 MAPKInterleukin RelatedTNF ReceptorNO SynthaseCOXNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRNitric oxide synthasesNOSCyclooxygenaseInhibitorinhibitorinhibit

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