Tallimustine (Synonyms: FCE 24517)

Cat. No.: HY-105270: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent.

For research use only. We do not sell to patients.

Tallimustine Chemical Structure

CAS No. : 115308-98-0

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Tallimustine:

Tallimustine hydrochloride Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent^[1]^[2]^[4].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	208 ng/mL Compound: 1h	Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells	10.1016/S0960-894X(97)10121-4
L1210	IC₅₀	48.9 nM Compound: tallimustine (TAM)	Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM) Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells,(cells resistant to melphalan (L-PAM)	[PMID: 15115402]
L1210	IC₅₀	50.3 ng/mL Compound: 1a	Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells Compound was tested in vitro for cytotoxicity after 48 hr of continuouse exposure against L1210 murine leukemia cells	10.1016/S0960-894X(97)10121-4
L1210	IC₅₀	55.3 nM Compound: tallimustine (TAM)	Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells Cytotoxicity was determined after 48 hr of continuous exposure against L1210 murine leukemia cells	[PMID: 15115402]

In Vitro

Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA^[1].
Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC₅₀ of 3.5 nM^[1].
Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells^[2].
Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells^[2].
Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	K562 cells
Concentration:	25 and 100 nM
Incubation Time:	4 days
Result:	Inhibited cell proliferation.

In Vivo

Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	L1210 tumor bearing mice^[2].
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Prolonged the survival of mice.

Clinical Trial

Molecular Weight

697.61

Formula

C₃₂H₃₈Cl₂N₁₀O₄

CAS No.

115308-98-0

SMILES

O=C(C1=CC=C(N(CCCl)CCCl)C=C1)NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCC(N)=N)=O)=C4)=O)=C3)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Herzig MC, et al. Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific. Biochemistry. 1999 Oct 19;38(42):14045-55. [Content Brief]

[2]. Bianchi N, et al. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol. 2001 Jun;113(4):951-61. [Content Brief]

[3]. Erba E, et al. Comparison of cell-cycle phase perturbations induced by the DNA-minor-groove alkylator tallimustine and by melphalan in the SW626 cell line. Int J Cancer. 1995 Jul 17;62(2):170-5. [Content Brief]

[4]. Tagliabue G, et al. Combination of the new minor groove alkylator tallimustine and melphalan. Eur J Cancer. 1997 Feb;33(2):284-7. [Content Brief]

Tallimustine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tallimustine115308-98-0FCE 24517FCE24517FCE-24517OthersAMLleukemiaK562L1210Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks