2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Dihydrofolate reductase (DHFR) Antifolate
  4. Talotrexin monoammonium

Talotrexin monoammonium  (Synonyms: PT523 monoammonium)

Cat. No.: HY-10824A
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Talotrexin monoammonium is the monoammonium salt form of Talotrexin (HY-10824). Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a reduced folate carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR to inhibit tumor growth.

For research use only. We do not sell to patients.

Talotrexin monoammonium Chemical Structure

Talotrexin monoammonium Chemical Structure

CAS No. : 648420-92-2

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Other Forms of Talotrexin monoammonium:

Talotrexin monoammonium Related Antibodies

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Description

Talotrexin monoammonium is the monoammonium salt form of Talotrexin (HY-10824). Talotrexin monoammonium is an analog of Aminopterin (HY-14518), and is a nonpolyglutamatable classic antifolate. Talotrexin monoammonium is a reduced folate carrier (RFC) specific inhibitor and selectively inhibits RFC transport. Talotrexin monoammonium shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].

Molecular Weight

590.59

Formula

C27H30N10O6
CAS No.
SMILES

NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2.N
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Talotrexin monoammonium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talotrexin monoammonium648420-92-2PT523 monoammoniumDihydrofolate reductase (DHFR)AntifolateR1-11Tet-on-RFCHeLa cellsDHFRreduced folate carrierantifolateNSCLCA549 tumorInhibitorinhibitorinhibit

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