2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR TAM Receptor
  4. PF-07265807

PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer.

For research use only. We do not sell to patients.

PF-07265807 Chemical Structure

PF-07265807 Chemical Structure

CAS No. : 2412356-57-9

Size Price Stock Quantity
5 mg USD 180 In-stock
10 mg USD 270 In-stock
25 mg USD 460 In-stock
50 mg USD 690 In-stock
100 mg USD 970 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

PF-07265807 Related Antibodies

Top Publications Citing Use of Products

View All TAM Receptor Isoform Specific Products:

View All Isoforms
Axl Mer Tyro3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer[1].

IC50 & Target

Axl

 

Tyro3

 

Mer

 

Molecular Weight

591.57

Formula

C29H27F2N7O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC[C@@H](C)NC1=NNC2=NC=CC(OC3=C(C=C(C=C3)NC(C(C(N4C5=CC=C(C=C5)F)=O)=CN(C(C)C)C4=O)=O)F)=C12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (338.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6904 mL 8.4521 mL 16.9042 mL
5 mM 0.3381 mL 1.6904 mL 3.3808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6904 mL 8.4521 mL 16.9042 mL 42.2604 mL
5 mM 0.3381 mL 1.6904 mL 3.3808 mL 8.4521 mL
10 mM 0.1690 mL 0.8452 mL 1.6904 mL 4.2260 mL
15 mM 0.1127 mL 0.5635 mL 1.1269 mL 2.8174 mL
20 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1130 mL
25 mM 0.0676 mL 0.3381 mL 0.6762 mL 1.6904 mL
30 mM 0.0563 mL 0.2817 mL 0.5635 mL 1.4087 mL
40 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0565 mL
50 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL
60 mM 0.0282 mL 0.1409 mL 0.2817 mL 0.7043 mL
80 mM 0.0211 mL 0.1057 mL 0.2113 mL 0.5283 mL
100 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4226 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PF-07265807 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-072658072412356-57-9PF07265807PF 07265807c-Met/HGFRTAM ReceptorTyro3AxlMerAnticancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PF-07265807
Cat. No.:
HY-147218
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.