2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Tap1a

Tap1a  (Synonyms: Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a)

Cat. No.: HY-P5865
Handling Instructions

Molarity Calculator

Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Tap1a Chemical Structure

Tap1a Chemical Structure

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Tap1a Related Antibodies

Top Publications Citing Use of Products

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Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that inhibits sodium channels with IC50s of 80 nM and 301 nM against Nav1.7 and Nav1.1, respectively. Tap1a shows analgesic effects[1].

IC50 & Target

IC50: 80 nM (Nav1.7), 301 nM (Nav1.1)[1]
Molecular Weight

4182.68

Formula

C174H258N52O55S7
Sequence

Asp-Asp-Cys-Leu-Gly-Met-Phe-Ser-Ser-Cys-Asp-Pro-Asn-Asn-Asp-Lys-Cys-Cys-Pro-Asn-Arg-Lys-Cys-Ser-Arg-Lys-Asp-Gln-Trp-Cys-Lys-Tyr-Gln-Leu-Trp (Disulfide bridge:Cys3-Cys18, Cys10-Cys23, Cys17-Cys30)
Sequence Shortening

DDCLGMFSSCDPNNDKCCPNRKCSRKDQWCKYQLW (Disulfide bridge:Cys3-Cys18, Cys10-Cys23, Cys17-Cys30)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tap1a Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tap1aTheraphotoxin-Tap1a TRTX-Tap1a µ/ω-TRTX-Tap1aSodium ChannelNa channelsNa+ channelsTheraphosa apophysisanalgesic effectpainful diabetic neuropathyspared nerve injury-induced neuropathychronic visceral painInhibitorinhibitorinhibit

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