TAT-MEK1

Cat. No.: HY-P10074: FAQs
Data Sheet Handling Instructions

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TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC₅₀ in vitro for ERK2 is 29 μM.

For research use only. We do not sell to patients.

TAT-MEK1 Chemical Structure

CAS No. : 566872-16-0

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ERK ERK1 ERK2 ERK5 ERK8

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Description

In Vitro

TAT-MEK1 (100 μM, 30 min) can inhibit luciferase activity in NIH.3T3 and PC12 cells , and inhibit the activation of ERK2sup>[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	NIH 3T3 and PC12
Concentration:	100 μM
Incubation Time:	30 min
Result:	Inhibited luciferase activity in cells and the activity of ERK2.

Molecular Weight

3146.77

Formula

C₁₃₆H₂₄₁N₅₃O₃₁S

CAS No.

566872-16-0

Sequence

Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2

Sequence Shortening

GYGRKKRRQRRRGMPKKKPTPIQLNP-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lukanowska M, et al. Bioportides: bioactive cell-penetrating peptides that modulate cellular dynamics. Biotechnol J. 2013 Aug;8(8):918-30. [Content Brief]

[2]. Kelemen BR, et al. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J Biol Chem. 2002 Mar 8;277(10):8741-8. [Content Brief]

TAT-MEK1 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-MEK1566872-16-0ERKExtracellular signal regulated kinasesInhibitorMAPKsMEK1inhibitorinhibit

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