2. Anti-infection
  3. Parasite
  4. TbPTR1 inhibitor 1

TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM).

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TbPTR1 inhibitor 1 Chemical Structure

TbPTR1 inhibitor 1 Chemical Structure

CAS No. : 2499713-65-2

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TbPTR1 inhibitor 1 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].

IC50 & Target

IC50: <0.1 nM (TbPTR1)[1]
Cellular Effect
Cell Line Type Value Description References
Macrophage CC50
25 μM
Compound: 5d
Cytotoxicity against human THP-1 derived macrophages by colorimetric MTT assay
Cytotoxicity against human THP-1 derived macrophages by colorimetric MTT assay
[PMID: 35675511]
Molecular Weight

399.45

Formula

C22H21N7O
CAS No.
SMILES

O=C(C1=CC=C(N(CC)CC2=CN=C(N=C(N)N=C3N)C3=N2)C=C1)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TbPTR1 inhibitor 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TbPTR1 inhibitor 12499713-65-2ParasiteTrypanosoma bruceiT. bruceiantiparasiticInhibitorinhibitorinhibit

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