TC299423

Cat. No.: HY-124110: FAQs
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TC299423 is an orally active, brain-penetrant, selective and potent agonist for α6β2^∗ and α4β2^∗ nicotinic acetylcholine receptors (nAChRs) with anxiolytic and antinociceptive properties. TC299423 acts primarily through α6β2^∗ nAChRs that are implicated in the anxiolytic effects of nicotine. TC299423 elicits reward-related behavior mediated through α6β2^∗ nAChRs in hypersensitive α6L90’S mice. TC299423 elicits dopamine release and dose not suppress nicotine self-administration in rats. TC299423 is proming for rasearch of addiction and Parkinson’s disease.

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TC299423 Chemical Structure

CAS No. : 1975146-56-5

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Description	TC299423 is an orally active, brain-penetrant, selective and potent agonist for α6β2^∗ and α4β2^∗ nicotinic acetylcholine receptors (nAChRs) with anxiolytic and antinociceptive properties. TC299423 acts primarily through α6β2^∗ nAChRs that are implicated in the anxiolytic effects of nicotine. TC299423 elicits reward-related behavior mediated through α6β2^∗ nAChRs in hypersensitive α6L90’S mice. TC299423 elicits dopamine release and dose not suppress nicotine self-administration in rats. TC299423 is proming for rasearch of addiction and Parkinson’s disease^[1]^[2].
Molecular Weight	189.26
Formula	C₁₁H₁₅N₃
CAS No.	1975146-56-5
SMILES	C1(/C2=CN=CN=C2)=C\CCNCCC1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Wall TR, et al. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017 Sep 26;8:641. [Content Brief] [2]. Post M R. Agonist Binding Studies at Two Subtypes of the Nicotinic Acetylcholine Receptor Involved in Parkinson’s Disease and Addiction[D]. California Institute of Technology, 2016.

TC299423 Related Classifications

Neurological Disease

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC2994231975146-56-5TC 299423TC-299423nAChRNicotinic acetylcholine receptorsorally activebrain-penetrantα6β2^? α4β2^? nAChRsanxiolyticantinociceptivereward-related behavioraddictionParkinson’s diseaseInhibitorinhibitorinhibit

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TC299423

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