TCO-PEG4-VC-PAB-MMAE

Name: TCO-PEG4-VC-PAB-MMAE
Brand: MedChemExpress
SKU: HY-148057
Rating: 4.5 (1 reviews)

Cat. No.: HY-148057 Purity: 99.30%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162). TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

TCO-PEG4-VC-PAB-MMAE Chemical Structure

CAS No. : 2758671-45-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162)^[1]. TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1522.91

Formula

C₇₈H₁₂₇N₁₁O₁₉

CAS No.

2758671-45-1

Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(OC4CC/C=C/CCC4)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (164.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6566 mL	3.2832 mL	6.5664 mL
5 mM	0.1313 mL	0.6566 mL	1.3133 mL
10 mM	0.0657 mL	0.3283 mL	0.6566 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.30%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (252 KB) HNMR (233 KB) RP-HPLC (254 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Yang Yi, et al. Preparation of site-specific antibody conjugates. Patent WO2022037665.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6566 mL	3.2832 mL	6.5664 mL	16.4159 mL
	5 mM	0.1313 mL	0.6566 mL	1.3133 mL	3.2832 mL
	10 mM	0.0657 mL	0.3283 mL	0.6566 mL	1.6416 mL
	15 mM	0.0438 mL	0.2189 mL	0.4378 mL	1.0944 mL
	20 mM	0.0328 mL	0.1642 mL	0.3283 mL	0.8208 mL
	25 mM	0.0263 mL	0.1313 mL	0.2627 mL	0.6566 mL
	30 mM	0.0219 mL	0.1094 mL	0.2189 mL	0.5472 mL
	40 mM	0.0164 mL	0.0821 mL	0.1642 mL	0.4104 mL
	50 mM	0.0131 mL	0.0657 mL	0.1313 mL	0.3283 mL
	60 mM	0.0109 mL	0.0547 mL	0.1094 mL	0.2736 mL
	80 mM	0.0082 mL	0.0410 mL	0.0821 mL	0.2052 mL
	100 mM	0.0066 mL	0.0328 mL	0.0657 mL	0.1642 mL