TCO-PEG8-NHS ester

Name: TCO-PEG8-NHS ester
Brand: MedChemExpress
SKU: HY-141169
Rating: 4.5 (1 reviews)

Cat. No.: HY-141169 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

TCO-PEG8-NHS ester Chemical Structure

CAS No. : 2353409-95-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TCO-PEG8-NHS ester:

(S,E)-TCO2-PEG8-NHS ester Get quote
(R,E)-TCO-PEG8-NHS ester Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

690.78

Formula

C₃₂H₅₄N₂O₁₄

CAS No.

2353409-95-5

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (144.76 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4476 mL	7.2382 mL	14.4764 mL
5 mM	0.2895 mL	1.4476 mL	2.8953 mL
10 mM	0.1448 mL	0.7238 mL	1.4476 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (240 KB) HNMR (278 KB) MS (67 KB)

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4476 mL	7.2382 mL	14.4764 mL	36.1910 mL
	5 mM	0.2895 mL	1.4476 mL	2.8953 mL	7.2382 mL
	10 mM	0.1448 mL	0.7238 mL	1.4476 mL	3.6191 mL
	15 mM	0.0965 mL	0.4825 mL	0.9651 mL	2.4127 mL
	20 mM	0.0724 mL	0.3619 mL	0.7238 mL	1.8095 mL
	25 mM	0.0579 mL	0.2895 mL	0.5791 mL	1.4476 mL
	30 mM	0.0483 mL	0.2413 mL	0.4825 mL	1.2064 mL
	40 mM	0.0362 mL	0.1810 mL	0.3619 mL	0.9048 mL
	50 mM	0.0290 mL	0.1448 mL	0.2895 mL	0.7238 mL
	60 mM	0.0241 mL	0.1206 mL	0.2413 mL	0.6032 mL
	80 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.4524 mL
	100 mM	0.0145 mL	0.0724 mL	0.1448 mL	0.3619 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.