2. PROTAC
  3. PROTAC Linkers
  4. TCO-PEG8-NHS ester

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

TCO-PEG8-NHS ester Chemical Structure

TCO-PEG8-NHS ester Chemical Structure

CAS No. : 2353409-95-5

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5 mg USD 105 In-stock
10 mg USD 160 In-stock
25 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of TCO-PEG8-NHS ester:

TCO-PEG8-NHS ester Related Antibodies

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Description

TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-PEG8-NHS ester Related Antibodies
Molecular Weight

690.78

Formula

C32H54N2O14
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (144.76 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4476 mL 7.2382 mL 14.4764 mL
5 mM 0.2895 mL 1.4476 mL 2.8953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4476 mL 7.2382 mL 14.4764 mL 36.1910 mL
5 mM 0.2895 mL 1.4476 mL 2.8953 mL 7.2382 mL
10 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
15 mM 0.0965 mL 0.4825 mL 0.9651 mL 2.4127 mL
20 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
25 mM 0.0579 mL 0.2895 mL 0.5791 mL 1.4476 mL
30 mM 0.0483 mL 0.2413 mL 0.4825 mL 1.2064 mL
40 mM 0.0362 mL 0.1810 mL 0.3619 mL 0.9048 mL
50 mM 0.0290 mL 0.1448 mL 0.2895 mL 0.7238 mL
60 mM 0.0241 mL 0.1206 mL 0.2413 mL 0.6032 mL
80 mM 0.0181 mL 0.0905 mL 0.1810 mL 0.4524 mL
100 mM 0.0145 mL 0.0724 mL 0.1448 mL 0.3619 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TCO-PEG8-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-PEG8-NHS ester2353409-95-5PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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