TD-802

Cat. No.: HY-146397: FAQs
Data Sheet Handling Instructions

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TD-802 (Compound 33c) is an androgen receptor (AR) PROTAC degrader with good microsomal stability. TD-802 has good antitumor efficacy in vivo and can be used for metastatic castration-resistant prostate cancer research.

For research use only. We do not sell to patients.

TD-802 Chemical Structure

CAS No. : 2760703-21-5

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	CC₅₀	0.098 μM Compound: 33c; TD-802	Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay	[PMID: 32961381]
VCaP	CC₅₀	0.044 μM Compound: 33c; TD-802	Antiproliferative activity against human VCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay Antiproliferative activity against human VCaP cells assessed as reduction in cell viability after 6 days by CellTiter-Glo assay	[PMID: 32961381]

Molecular Weight

957.56

Formula

C₅₂H₆₁ClN₁₀O₆

CAS No.

2760703-21-5

SMILES

CC1([C@@H](C(C)([C@H]1OC2=CC(Cl)=C(C=C2)C#N)C)NC(C3=CC=C(C=C3)N4CCN(CC4)C5CC6(C5)CCN(CC6)C(C7CCN(CC7)C8=CC=C9N=NN(C(C9=C8)=O)C%10CCC(NC%10=O)=O)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takwale AD, et al. Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras. Eur J Med Chem. 2020 Dec 15;208:112769. [Content Brief]

TD-802 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TD-8022760703-21-5TD802TD 802PROTACsAndrogen Receptormicrosomal stabilityproteolysis-targeting chimeraprostate cancerInhibitorinhibitorinhibit

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