2. Apoptosis Stem Cell/Wnt JAK/STAT Signaling
  3. MDM-2/p53 STAT Apoptosis
  4. TDP-665759

TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models.

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TDP-665759 Chemical Structure

TDP-665759 Chemical Structure

CAS No. : 787632-66-0

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TDP-665759 Related Antibodies

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Description

TDP-665759 is an inhibitor for HDm2:p53 complex, and thus activates p53, inhibits STAT3 signaling pathway (EC50 of 5.90 μM) and the cell viability of p53 expressing A549R (IC50 of 7.02 μM). TDP-665759 induces apoptosis in HepG2. TDP-665759 exhibits antitumor efficacy in mouse models[1].

Molecular Weight

706.44

Formula

C31H34Cl2IN5O2
CAS No.
SMILES

O=C([C@H](C1=CC=C(Cl)C=C1)N2[C@@H](C3=CC=C(Cl)C=C3N)C)N(CCCN4CCN(C)CC4)C5=CC=C(I)C=C5C2=O
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Room temperature in continental US; may vary elsewhere.
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TDP-665759 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDP-665759787632-66-0TDP665759TDP 665759MDM-2/p53STATApoptosisJAR choriocarcinomaA549HepG2BALB/c mousemelanomaInhibitorinhibitorinhibit

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