2. Stem Cell/Wnt
  3. YAP
  4. TEAD-IN-19

TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, exhibiting inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% against TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at a concentration of 10 μM. TEAD-IN-19 shows potent anti-proliferative and anti-migratory activities in prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds promise for research in the field of cancer therapy.

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TEAD-IN-19 Chemical Structure

TEAD-IN-19 Chemical Structure

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TEAD-IN-19 Related Antibodies

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YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

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Description

TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, exhibiting inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% against TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at a concentration of 10 μM. TEAD-IN-19 shows potent anti-proliferative and anti-migratory activities in prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds promise for research in the field of cancer therapy[1].

Molecular Weight

510.97

Formula

C33H19ClN2O2
SMILES

CN(C1=CC=CC=C1C(O)=O)C(C=C2)=CC=C2NC(C=C3)=C(Cl)C=C3C4567C89%10C%11%12(C%10%136(C)C%14%15%167)C%17%13%16C%11%18%19C%128%20C49%21C%22%155C%18%17%14C%19%20%21%22
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TEAD-IN-19 Related Classifications

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Keywords:

TEAD-IN-19YAPYes-associated proteinInhibitorinhibitorinhibit

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HY-173139
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