2. Anti-infection
  3. Penicillin-binding protein (PBP) Bacterial Antibiotic
  4. Tebipenem pivoxil hydrochloride

Tebipenem pivoxil hydrochloride  (Synonyms: L084 hydrochloride)

Cat. No.: HY-B0396A
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Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis.

For research use only. We do not sell to patients.

Tebipenem pivoxil hydrochloride Chemical Structure

Tebipenem pivoxil hydrochloride Chemical Structure

CAS No. : 211558-19-9

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Tebipenem pivoxil hydrochloride Related Antibodies

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Description

Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis[1].

IC50 & Target

β-lactam

 

In Vitro

Tebipenem pivoxil hydrochloride (0-128 μg/mL, 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tebipenem pivoxil hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: Gram-positive and Gram-negative bacteria
Concentration: 0-128 μg/mL
Incubation Time: 18–24 h
Result: Showed inhibition with MIC50s below 64 μg/mL against tested Gram-positive and Gram-negative bacteria.
In Vivo

Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) hydrochloride shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice[1].
Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) hydrochloride significantly protects the sepsis mice challenged with various pathogenic bacteria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM mice weighing 18–22 g[1]
Dosage: 2.89, 3.40 and 4.00 g/kg
Administration: Oral administration (tablet), once
Result: Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage.
Animal Model: ICR mice, sepsis mouse models[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration (tablet), once
Result: Significantly increased the survival number of the sepsis mice within a 168 h observation period.
Clinical Trial
Molecular Weight

534.09

Formula

C22H32ClN3O6S2
CAS No.
SMILES

CC(C)(C)C(OCOC(C1=C(SC2CN(C3=NCCS3)C2)[C@H](C)[C@@]([C@@]4([H])[C@H](O)C)([H])N1C4=O)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tebipenem pivoxil hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tebipenem pivoxil211558-19-9L084L 084L-084Penicillin-binding protein (PBP)BacterialAntibioticbroad antibacterial spectrumStreptococcus pneumoniaErythromycin-resistant Streptococcus pneumoniaHaemophilus influenzaorally activepenicillin-binding proteinInhibitorinhibitorinhibit

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